Chevy Chase was already a box office star when he took on the role of Clark Griswold for the third time. He was commanding big bucks thanks to the success of Caddyshack, the first Vacation movie and Fletch, but his career started to stall after a succession of box office bombs followed by a short-lived talk show. In 2009, however, the comedian re-entered the spotlight as Pierce Hawthorne on the hit sitcom Community. His success lasted fewer than four seasons, however, as the actor engaged in a highly publicized feud with series creator Dan Harmon
Beverly D’Angelo as Ellen
Never mind the fact that Beverly D’Angelo appeared in Annie Hall and Coal Miner’s Daughter — she’s best known as Ellen Griswold, the ever-loyal Griswold matriarch. Following her movie success in the 1980s, she went on to appear in such films as Pacific Heights, American History X, Harold & Kumar Escape from Guantanamo Bay, and The House Bunny. In 1988, she met Al Pacino on the set of Sea of Love. The couple had twins together but never married.
Juliette Lewis as Audrey
Although a household name nowadays, Juliette Lewis was relatively unknown when she first appeared as Audrey Griswold. Her big hit came years later when she was cast by Martin Scorsese in his 1991 film, Cape Fear. Her largely improvised “thumb-sucking” scene with Robert De Niro punctuated an award-winning performance and led to roles on Woody Allen’s Husband and Wives, What’s Eating Gilbert Grape (opposite Johnny Depp) and Oliver Stone’s Natural Born Killers. In 2012, she starred on the short-lived network drama
Johnny Galecki as Rusty
Chase might consider television sitcoms the lowest form of comedy, but that probably doesn’t bother Johnny Galecki. From 2007 to 2019, Galecki starred in the hit comedy The Big Bang Theory, in which he plays the physicist Leonard Hofstadter.
Randy Quaid and Cousin Eddie
The Oscar-nominated actor followed up his role as the Hamburger Helper-loving army vet with roles in Independence Day, Kingpin and Brokeback Mountain. However, in 2010, he and his wife were arrested for causing more than $5,000 in damage at a rental house. The couple fled to Vancouver, claiming a cabal of Hollywood executives and lawyers were out to destroy them and has claimed that they had a hand in the deaths of actors David Carradine and Heath Ledger. He and his wife eventually made their way to Vermont where authorities have forced them to remain.